星期日, 4月 06, 2025

波士頓3科學家獲2025突破獎 劉如謙得獎金300萬元

劉如謙。圖片來自維基百科。
              (Boston Orange 綜合編譯) 突破獎 ( The Breakthrough Prize )基金會45日宣佈2025年有6名得獎人,各得300萬元獎金,包括博德 研究院(Broad Institute) 的哈佛教授劉如謙,其中3人位於麻州。

              突破獎由Sergey BrinAnne WojcickiPriscilla Chan和馬克札伯格 (Mark Zuckerberg)Julia Yuri Milner3對夫婦創立,有有科學界奧斯卡之譽,表揚在科學上有成就者。

              這獎項發給生命科學、基礎物理,以及數學領域的每名得獎者300萬元。今年這第13年,突破獎基金會增設新地平線獎 (New Horizons Prize),有8名還在職涯早期的物理家及數學家,將分享610萬元獎金。最近剛完成博士學位的3名女性數學家將各獲得5萬元獎金的Maryam Mirzakhani 新前沿獎 (New Frontiers Prize)

              今年獎金總額共1875萬元,使得這獎項14年來發出的獎額總數超過32600萬元。

              生命科學領域的得獎人,有3組人。

              劉如謙 (David R. Liu ) 因為研發出2種強而有力,被廣泛使用的基因編輯技術而獲獎。

              他的這些技術是以分子機械工程來糾正導致病人患遺傳性疾病的基金突變。更重要的是,這做法不需要剪除DNA的雙螺旋體,減少人們不希望出現的結果。

              2016年,劉如謙的實驗室研發出鹼基編輯 (base editing),糾正了約佔導致基因疾病突變30%的單字母拼寫錯誤

              2019年,劉如謙實驗室發明了引導編輯 (Prime editing),能夠用校正後的基因來取代整段有缺陷的基因,而且幾乎可以修補所有疾病導致的突變。這些技術已經分送到世界各地的實驗室2萬多次,帶來研究、農業及生物醫藥上數以千計的進展文章發表。

              在動物身上,鹼基編輯和引導編輯已成功的糾正突變並拯救了例如鐮狀細胞病和 β-地中海貧血,神經系統疾病,如ALS和脊髓性肌萎縮症 SMA),肌肉疾病,如肌肉萎縮症和心肌病,遺傳形式的失明,遺傳形式的聽力損失,幾種代謝紊亂和早衰症,一種過早衰老的疾病。

              5個國家裏,已至少 15 項鹼基編輯和引導編輯在做臨床試驗,已經證實在治療T細胞白血病,鐮狀細胞病、β-地中海貧血症和高膽固醇患者尚有校,有時候甚至拯救了生命。

              另外2組人,一組為Daniel J. Drucker, Joel Habener, Jens Juul Holst, Lotte Bjerre Knudsen and Svetlana Mojsov 5名科學,從基礎荷爾蒙發現到生理理解到製藥發展有互補貢獻,帶來治療糖尿病和肥胖症的高效藥物,開創了治療心臟代謝疾病的 GLP-1 藥物的新時代。

              另一組的Stephen L. Hauser  Alberto Ascherio 。這兩名研究員改變了人們對多發性硬化症 MS 的理解和治療,確定免疫系統的 B 細胞是神經細胞損傷的主要驅動因素。多發性硬化症 MS 是一種使人衰弱的神經退行性疾病,其中免疫系統攻擊神經纖維周圍的絕緣蛋白。

              突破獎的基礎物理獎頒給在 CERN 大型強子對撞機 LHC 的四個實驗合作 ATLASCMSALICE LHCb項目中工作,來自70個國家的的數以千計研究人員。

              這基礎物理突破獎的300萬元獎金,分給ATLAS 100萬元,CMS 100萬元,ALICE50萬元,LHCb50萬元。表揚用LHC Run 22015年到2024715日之間所發表數據為基礎,撰寫發表文章的13508名共同作者。

              突破獎基金會諮詢實驗領導後,將捐出100%的獎金,給CERN及社會基金,用來提供補助給會員組織的博士學生。

              數學類突破獎頒給Dennis Gaitsgory ,表揚他在證明幾何朗蘭茲猜想 (the geometric Langlands conjecture)上的核心角色。

              在基礎物理上的特別突破獎,頒給Gerard 't Hooft,這位世界上最傑出的物理理論學家之一。 (更新版)

星期五, 4月 04, 2025

MAYOR MICHELLE WU CELEBRATES GRADUATION OF FOURTH POWERCORPS BOSTON COHORT

MAYOR MICHELLE WU CELEBRATES GRADUATION OF FOURTH POWERCORPS BOSTON COHORT


This marks the first graduation since the program's expansion from six months to ten months 


BOSTON - Friday, April 4, 2025 - Yesterday, Mayor Michelle Wu celebrated the graduation of PowerCorps Boston's fourth cohort. PowerCorps Boston is the City’s green industry workforce development program that prepares young adults for careers addressing Boston’s most pressing environmental challenges. The 22 graduates spent the past ten months learning about various green industries and acquiring skills in urban forestry, urban greening, and energy-efficient building operations and maintenance.


“You’ve done so much to make our neighborhoods more vibrant, more beautiful and more resilient places for all of our communities,” said Mayor Michelle Wu. “PowerCorps is one of the programs that we are most proud of.”


Led by the Worker Empowerment Cabinet in partnership with the Environment Department, PowerCorps Boston is a “learn and earn” program that pays Boston’s young adults aged 18-30 to participate in hands-on training while providing career readiness support and connections to employers in the green industry. The program prioritizes marginalized groups, including residents from environmental justice communities, returning citizens, court-involved residents, youth who have experienced homelessness or housing instability, and youth who have been in foster care. 


"PowerCorpsBOS is building Boston’s green workforce while investing in our young people,” said Brian Swett, Chief Climate Officer. “Expanding to ten months means deeper skills, more diverse career pathways, and greater impact. These graduates are helping make Boston more resilient and sustainable, and I look forward to seeing their contributions grow."


“I am incredibly proud of our graduates,” said Davo Jefferson, Executive Director of PowerCorps Boston. “This marks the first cohort to graduate under PowerCorps Boston’s 10-month model — a significant accomplishment that speaks to their commitment to improving their lives and their city. These successes were made possible thanks to the support of our green industry partners, who not only helped train this skilled group of young adults but also went on to employ many of them. PowerCorps Boston will continue to create these opportunities that foster economic mobility for our residents while creating a climate-resilient city.” 


Last year, the program was expanded from six months to 10 months to offer Corps members a more comprehensive and immersive experience. This new format includes two phases: 


  • The first phase, Foundations, is a four-month training program where participants focus on workforce-readiness skills, are introduced to green industry careers, and receive necessary support services to complete the program. This phase combines training in soft skills and environmental hard skills applicable for employment in the green industry and beyond. 


  • The second phase, Industry Academy, is a six-month training where participants choose to specialize in one of the three tracks:
  • Urban Forestry: The study of arboriculture, including topics like soils, urban tree stressors, and pruning techniques. 
  • Building Operations: A hybrid training model of college-level courses and on-the-job training about operating and maintaining buildings at peak efficiency..
  • Urban Greening: A focus on green infrastructure, urban agriculture, and natural resource management.


To create a climate-ready city, we must cultivate a climate-ready workforce. To advance this mission, PowerCorps Boston collaborates with over 60 non-profits, higher education institutions, and private sector organizations in Boston’s green industry to offer participants high-quality, hands-on training opportunities along with classroom learning. These partnerships enable participants to gain valuable experience and education while addressing various projects that enhance Boston’s climate resilience.


”As we celebrate today’s graduates, we extend our gratitude to Mayor Wu for her vision and leadership, to the PowerCorps team for their partnership, and to our member companies and institutions for their commitment,” said Yve Torrie, Director of Climate, Energy, and Resilience at A Better City. “The PowerCorpsBOS Building Operations program, which trains Boston residents to maintain energy-efficient buildings crucial to the city's climate goals, directly addresses immediate workforce gaps and creates a pipeline for the green jobs of tomorrow. Together, we have developed and updated the curriculum, shared lessons learned, and collaborated with members and partners to provide paid, in-service learning opportunities that lead to employment. Thanks to A Better City members and partners, five of the 12 participants in the current cohort have secured jobs, and three have extended internships aimed at full-time employment.


The participants in Urban Greening and Urban Forestry have enhanced 233 acres of public land, removed 248 bags of invasive materials to improve the health of local ecosystems, planted 43 trees to increase urban greening and improve air quality, and assisted the Food Project in growing 25,000 lbs of produce to support local food security. 


The Building Operations participants have interned at 13 large building sites over six months, working on energy-efficient general maintenance and operations, including HVAC, electrical, and plumbing work.


Urban Greening and Urban Forestry participants have earned three college credits in Arboriculture from UMass Amherst’s Mount Ida campus and the Building Operations participants have earned multiple industry-recognized credentials including OSHA 10 Construction Safety & Health Certification, Building Science Principles (BPI) Certification, Green Professional Training (GPRO) Certification, EPA Section 608 Certification, ‘Hot Works’ Certification for MA, and Fundamentals of Energy Efficient Building Operations (FEEBO) Certification.


“Whether it was sitting through 10 hours of OSHA classes, spending long days in the sun or rain clearing Japanese knotweed, or learning valuable life skills in class—Power Corps Boston has transformed my mindset and my trajectory,” said PowerCorps Boston Participant, Lagene Jones-Richardson. “I hope to use this transformation to create real change, not just in myself, but in the world around me.”


As employers actively recruit from PowerCorps Boston's skilled, diverse talent pool, they fill vacant jobs in emerging industries and create new opportunities for the participants. Of the 22 graduates, 17 have secured green industry job placements with employers like the City of Boston, Zoo New England, Barrett Tree Services, Parterre Gardens, Forge, BXP, WS Development, C&W Services, Equity Residential, Northeastern University, Schneider Electric, and L.C. Anderson.


They will be undertaking various roles as Tree Equipment Operators, Plant Health Care Technicians, HVAC Apprentices, Facilities Technicians, and more with competitive wages that reflect the value they bring to their respective organizations. Participants of the Urban Forestry and Urban Greening track have secured job placements with an average salary of $21.85/hr. Participants of the Building Operations track have an average salary of $27.20/hr. 


“We’ve had good days, we’ve had tough days, but through it all, we’ve stood together as a family,” said PowerCorps Boston Participant Rasaun Harris. “More than anything, we share a common goal: to make the city of Boston a cleaner, healthier, and more sustainable place.” 


PowerCorpsBoston is now accepting applications. Training begins May 2025. To be eligible for this program, you must: 



  • be 18-30 years old; 
  • be a Boston resident; 
  • have your high school diploma or its equivalent (GED/HiSET); 
  • be unemployed or underemployed and not in college or on a career track 
  • have an interest in outdoor, and/or hands-on training. 


Learn more and apply at boston.gov/powercorps.

哈佛的亞裔領導力倡議春季高峰會請Daniel Dae Kim、趙小蘭、蘇維思等人分享經驗

左起,趙小蘭, 金大賢,以及趙小蘭之妹(右一)。(周菊子攝)
                (Boston Orange 周菊子劍橋市報導) 亞裔領導力倡議 (The Asian Leadership Initiative,簡稱ALI) 和亞美基金會 (The Asian American Foundation,簡稱TAAF) 合作, 330日在麻州劍橋市查理士酒店舉辦首屆春季高峰會,邀得

8名亞裔名人和200多名年輕學子晤談,分享、傳承經驗。

會議由ALI哈佛大學分會主席Daniel Bai開場,韓裔明星金大賢

趙小蘭(中)兩姊妹和亞美基金會共主席Joseph Bae。(周菊子攝)
(Daniel Dae Kim),美國前勞工部及交通部部長趙小蘭 (Elaine Chao),美國聯邦參議員Tammy Duckworth,私募基金KKR 共執行長Joseph Bae依序以接受訪談形式分享經驗後,美國前勞工部長蘇維思 (Julie Su) ,武田製藥候任執行長Julie Kim,哈佛大學講師,也是創業家的Rushika FernandopulleTAAF政府關係主任Sam Huyn聯席座談。

韓裔明星金大賢 (Daniel Dae Kim) 近年積極為雅美人發聲。(周菊子攝)
這場ALI首屆春季高峰會旨在拓展亞裔年輕人視野,提供交流,建立人脈關係機會的活動,出席者絕大多數是年輕學子,在提問環節,還有人表白自己是來自中東學生。

金大賢是一位以「天堂执法者 (Hawaii Five-0) 」等電視劇而聞名的演員,但近年來他為亞裔美人發聲的事蹟,讓他更受矚目。30日這天,他在亞裔領導力倡議春季高峰會中的發言,和2020年他為「亞裔美國人」這公視記錄片接受訪問時的談到的幾乎一樣。

主持人Daniel Bae (左起)、分享人Julie Kim,蘇維斯,Sam Hyun。 (周菊子攝)
他問出席者,有多少人知道黃金德 (Wong Kim Ark)、陳果仁是誰? 如果不知道的話,大家有很多功課要做。

金大賢藉此闡述,在美國成長的亞裔,很多人不知道亞裔在美國歷史中曾有過的遭遇,例如1882年的排華法案,二戰時期的日本集中營,1992年的火燒洛杉磯韓國城,這些一般美國歷史課本中沒有的亞裔美人歷史,如果亞裔自己都不知道,又如何爭取亞裔在美國的社會地位。

聯邦參議員Tammy Duckworth從網上參會。(周菊子攝)
黃金德 (Wong Kim Ark) 是在美出生的華裔第二代。他從中國探親返美時,竟因1882年通過的排華法案,被禁止入境,還被逮捕,關押在他所乘坐的船上。幸而當年的中華會館(CCBA)以他是美國憲法14章修正案中的土生土長公民,卻被非法居留,為他申請人身保護令。這案件最後被提交至最高法院,並以62票支持黃金德案論點,從而為所有移民確立了與生俱來的公民權。

Sam Hyun如今擔任TAAF的政府關係主任。(周菊子攝)
陳果仁事件則是1882年時,日本汽車進口,導致美國汽車工人失業率大增,密西根州美籍華裔製圖員陳果仁和朋友在俱樂部舉行婚前單身派對時,和2名汽車工人發生口角,被毆打致死。肇事者起初被控二級謀殺罪,之後降為誤殺罪,還以罰款3千元,3年緩刑結案,連入獄都沒有,人命輕賤得有如現代的「黑命貴」申訴。

ALI春季高峰會出席者大都是在校學生。(周菊子攝)
趙小蘭以非常輕鬆地話家常態度和年輕學子們交流。她以自己的家庭為例,指出亞裔都很重視家庭、家族,彼此扶攜。她談到要成功,就得永不放棄的堅持。笑說勞工部和交通部相比,她更喜歡當勞工部部長,因為所有人都向她匯報,制定的決策,影響深遠。交通部則是麾下許多單位,都是歷史悠久,原本就已存在的組織,有各自的完整人事架構,一般情況下,她只需要了解,然後向總統報告而已。

亞裔領導力倡議是個由年輕學子組成,為培育亞裔下一代領袖,提供支援環境,為年輕人和有成就專業人士架起輔導、學習橋梁的組織。目前有哈佛、芝加哥大學、加州大學柏克萊分校 (UC Berkeley)3個分會。亞美基金會 (TAAF)十分重視這次的春季高峰會,不單只董事會共同主席Joseph Bae親自出馬當講者,最近才獲頒影響力獎的TAAF執行長陳立實 (Norman Chen)也全程在場。

TAAF的政府關係主任Sam Hyun曾任職麻州議會,也應波士頓市長吳弭邀請,曾任波士頓市聯邦政府關係主任。

TAAF10人董事會,除了前述的Josephy Bae,陳立實外,還有城堡證券(Citadel Securities) 執行長趙鵬,喜瑪拉雅資本創辦人李祿,阿里巴巴集團共同創辦人蔡崇信,雅虎共同創辦人楊致遠等人。

哈佛MIT學術白話文八乘八 考驗學子深入淺出能力

哈佛大學和麻省理工學院合作的「學術白話文」,出席者合影。(周菊子攝)
                (Boston Orange 周菊子波士頓報導) 哈佛大學和麻省理工學院合作的「學術白話文」系列,2025年首場,擴大為八乘八。330日在哈佛大學馮氏禮堂舉行,內容多元、精彩,60多人數度爆笑。

蔡孟勳組長(右三)頒發感謝狀給哈佛大學和麻省理工學院合作的
「學術白話文」系列講者。
(周菊子攝)
                             這天的8名講者,波士頓經文處科技組長蔡孟勳是「神秘嘉賓」,另外7人及講題分別為,哈佛設計學院建築暨都市設計碩士生高采薇談結合都市規劃與建築設計案例;MIT數據系統小組何達睿談藉影像捕捉時間相關特徵,提升大型編碼器性能;MIT媒體實驗室博士生楊浩東談用微型刺激裝置來療帕金森症等神經退化性疾病;約翰霍普金斯大學天文物理博士生蕭予揚談以100億美金打造的全世界首座紅外線太空望遠鏡JWST,如何拓展人類對宇宙的認知;成功大學資訊工程博士生蔡沛蓁分享用人工智慧提升病理診斷的準確性與效率;
波士頓經文處科技組長蔡孟勳分享「DNA能說什麼故事
 (What Story Can DNA Tell)」。(周菊子攝)
MIT博士後研究員陳麒方分享量子演算法 及熱力學,哈佛大學比較動物學博物館博士後研究學者詹偉平以生動有趣方法談氣候與環境議題。

           蔡孟勳的「DNA能說什麼故事 (What Story Can DNA Tell)」,從他當年在陽明大學公衛研究所讀博時,台灣發生的輻射屋這公衛事件說起。研究結果證實,有些房子的鋼筋水泥裏藏有受輻射汙染物,長年住在那些房子裡的人受輻射影響,患癌機會更高。這些人後來打贏國賠官司。

哈佛大學臺灣學生會會長李典璋()、共會長陳曦()感謝特別嘉賓講者,
波士頓經文處科技組長蔡孟勳。
(周菊子攝)
              蔡孟勳還以台灣特有物種帝雉、梅花鹿,外來的火蟻等物種為例,指出人與環境都有DNA定序,可互相影響,形成DNA的改變與細胞革命。研究DNA其實有非常多有趣故事。

              當天的出席者中包括曾任哈佛會長的蕭育舜,MIT會長的陳韋同。分享同學中詹偉平的陳述方式最為特殊。他把現場同學依座位分成高山、平原,再藉轉傳海灘球描述影響氣候變遷因素。

哈佛臺灣學生會會長李典璋 (),副會長陳曦,學術總召曾昱瑄介紹該會幹部。
(周菊子攝)
              哈佛學生會長李典璋在開場前介紹了共會長陳曦,學術總召曾昱瑄等幹部。原本預告,談國民法官制與健保的臺灣咖啡館講座,後因講者人選引發爭論取消。

哈佛設計學院建築暨都市設計碩士生高采薇談結合都市規劃與建築設計案例

MIT博士後研究員陳麒方分享量子演算法 及熱力學。
哈佛大學比較動物學博物館博士後研究學者詹偉平以生動有趣方法談氣候與環境議題。
約翰霍普金斯大學天文物理博士生蕭予揚談以100億美金打造的全世界
首座紅外線太空望遠鏡
JWST,如何拓展人類對宇宙的認知。
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麻州科技卿 Jason Snyder 獲得全國效率及創新獎

Technology Secretary Jason Snyder Receives National Award for Efficiency, Effectiveness and Innovation 

Wins StateScoop “Golden Gov” award; Honored among governors and chief technology officers from across the country  

BOSTON – The Healey-Driscoll Administration is proud to announce that Massachusetts Technology Secretary and Commonwealth Chief Information Officer Jason Snyder has been honored with the StateScoop “Golden Gov” award for his exceptional leadership in driving efficiency, effectiveness and innovation. This award recognizes Secretary Snyder’s commitment to driving innovation within the Executive Office of Technoloy Services and Security (TSS) and the broader IT business in the executive branch. 

“Massachusetts is a global leader in attracting, educating and developing the technology and people that power the modern world, but we also set an example within state government,” said Governor Maura Healey. “Secretary Snyder leads our technology strategy within government, and those efforts make a real difference in people’s lives by improving a residents’ digital experience with government and making our state IT systems more secure. I want to congratulate Secretary Snyder for this well-deserved recognition from StateScoop, and we are so excited to see him receive the award in person at NASCIO later this month.” 

“We’ve always known how lucky we are to have Secretary Snyder overseeing technology services and security for Massachusetts, and it’s wonderful to see his leadership recognized on the national stage,” said Lieutenant Governor Kim Driscoll. “His efforts have made it easier for Massachusetts residents to access government services and resources online and strengthened our efforts to keep people’s information safe and secure.” 

“I am honored to accept the Golden Gov award on behalf of the incredible, hardworking staff at TSS,” said Technology Services and Security Secretary Jason Snyder. “The public servants who advance technology in Massachusetts state government are some of the best at what they do, and this award is due to an ongoing team effort at all levels of our state IT enterprise. We are laser-focused on using technology to improve government service delivery for all our residents, and this award shines a light on that work. I thank StateScoop for recognizing Massachusetts and presenting me with this award.” 

Under Secretary Snyder’s leadership, Massachusetts has had a transformational year in technology, in which Governor Healey signed into law a new five-year capital authorization known as the FutureTech Act. This past year, TSS also focused its operations on mitigating critical IT system vulnerabilities and making strides to provide a simple, secure and accessible digital experience for all residents, through both a multi-year digital roadmap and the creation of a new enterprise digital accessibility team that provides standards, trainings and resources to state agencies to ensure that state digital services and information are accessible to all. 

Secretary Snyder also co-led the Governor’s AI Strategic Task Force, alongside Economic Development Secretary Yvonne Hao, which produced its final report and recommendations in December. A core component of those recommendations was to expand access to high-performance computing that is necessary for AI innovation, while maintaining the Healey-Driscoll Administration’s priority of tapping sustainable resources. Secretary Snyder is working with the Massachusetts Green High Performance Computer Center (MGHPCC) in Holyoke and its higher education members to expand that access in the coming months for public and private higher education institutions, startups and businesses. 

Last year, TSS received two awards recognizing Massachusetts strategy to improve the resident digital experience: the NASCIO award for government-to-citizen digital experience, and the Center for Digital Government’s Government Experience (GovX) first place award. The foundation for this enhanced digital experience is the MyMassGov single sign-on credential that manages a single resident identity across state services, providing both ease of use and the prevention of fraudulent access. That work has continued this year, with multiple additional business applications now integrated into the single sign-on and more planned throughout calendar year 2025.  

Other award winners this year include state governors, lieutenant governors, state Chief Information Officers, state Chief Technology Officers, and Information Security Officers. Secretary Snyder will receive the award at the National Association of State Chief Information Officers (NASCIO) Midyear Conference in Philadelphia in late-April. 

About StateScoop 

StateScoop is a publication covering state and local government. With more than 6.5M monthly unique engagements, StateScoop reports on news and events impacting technology decisions in state and local government. They bring together IT leaders and innovators from across government, academia and industry to exchange best practices and identify ways to engage with and improve state and local government. 

About EOTSS 

As the state’s lead technology secretariat, EOTSS is charged with the responsibility of coordinating the Administration’s information technology activities and ensuring that all executive department agencies adhere to its published standards, policies, and procedures. This enterprise approach provides a single, comprehensive framework to ensure that the state is in alignment to protect the confidentiality, integrity and availability of the Commonwealth’s data and information systems.